Dolce Gabbana Belt
Mom's Placenta Reflects Her Exposure to Stress and Impacts Offsprings' Brains, University of Pennsylvania Study More Regular Meals May Improve Dementia Care, Journal of Advanced Nursing Reveals
Vienna, Austria, March 7, 2013 / B3C newswire / The European Medicines Agency recently awarded the Austrian biotech company Activartis an Orphan Drug Designation for its innovative Cancer Immune Therapy AV0113. The Orphan Drug Designation applies specifically to the use of AV0113 for the treatment of glioma, a type of brain tumour, which afflicts around one in 10.000 people in the EU. The term Orphan Disease refers Dolce Gabbana Belt to rare diseases which do not attract much interest in the way of research and development Ferragamo Belts
The director of the team that developed this new form of Cancer Immune Therapy, Thomas Felzmann, who is now CEO of Activartis, says: "Acquiring orphan drug designation is an important milestone for us and a strong signal to others. We are convinced that this approach has great potential and now an independent party, the European Medicines Agency, has confirmed this. However, it will still take another year or so before robust evidence for a benefit of AV0113 for patient's suffering from Glioblastoma will become available."
Due to their rarity biomedical research and development often neglects rare diseases. Consequently, such diseases are referred to as orphans. Advantages conferred by an Orphan Drug Designation include an accelerated approval procedure and market exclusivity in Europe for ten years from the date of approval and seven years in the USA. As a result, Orphan Drug Designation promotes the development of medication for people who are afflicted by rare, life threatening diseases.
Obese Moms Increase Heart Attack Risk for Their Infants, University of Sydney Study Missed Meals in Childhood Linked Gucci Belt East London
and thus for which there are no appropriate treatments available.
Activartis Biotech GmbH Receives Orphan Drug Designation for Its Cancer Immune Therapy AV0113
In order to award an orphan drug designation, the EMA requires preliminary indications that the medicine concerned may be effective but yet not any definitive proof. Activartis has now been able to provide such indications in the case of patients with a particularly aggressive type of glioma, Glioblastoma multiforme. Every year about 50.000 people around the world are diagnosed with this aggressive type of brain tumour. Patients afflicted by Glioblastoma do not live much longer than one year on average. More than 90% of patients die within a five year period. The classic forms of cancer therapy surgery, irradiation and chemotherapy only extend the lives of patients by a few months.
As tumour cells originate from a cancer patient's normal cells, they do not provide such danger molecules for recognition by the Dendritic Cell. The critical and unique part of Activartis' AV0113 technology is exposing tumour antigen charged Dendritic Cells to one of these danger molecules: Lipopolysaccharides, the bacterial endotoxins. This causes the Dendritic Cell to assume a potently immune stimulatory and pro inflammatory mode of action. Upon returning these Dendritic Cells to the patient they activate tumour specific T cells, most importantly the so called Cytotoxic T cells, which become enabled to recognise and destroy tumour cells.
Insomnia Linked to Increased Risk of Heart Failure, Norwegian University of Science and Technology Study More Iron Linked to Reduced Risk of Severe PMS, University of Massachusetts Amherst Study
AV0113 activates the patient's immune system, with tumour cells being identified on the basis of their antigens and destroyed. The therapy makes use of elements and mechanisms of the immune system and gets to work where these fail. As tumour cells are the body's own tissue, the immune system normally doesn't identify them as dangerous. to perceive the tumour as a threat and to trigger adequate defence mechanisms.
HIV Linked to Higher Chance of Heart Attack, University of Pittsburgh Study Children's Brains Transform Subconsciously Learned Material Into Active Knowledge, University of Tubingen Study
With Pain, Depression in Adulthood, University of Nebraska Lincoln Study
The majority of neuro surgical/neuro oncological clinics in Austria currently Gucci Belt Red And Black
Keyword: Orphan Drug Designation
Activartis' AV0113 Cancer Immune Therapy can basically be used to fight every type of cancer. The therapeutic technology is based on a patented procedure in which a cancer patient's immune system is primed to fight the tumour and eventually control its growth. This is based on the use of Dendritic Cells, the key regulatory elements of the immune system, that are just as the tumour tissue derived from the patient.
Activartis Biotech GmbH to Present at Biotechnology Industry Organization (BIO) Europe 2011 on Nov 1, 2011, in Duesseldorf, DE Strains of Antibiotic Resistant "Staph" Bacteria Show Seasonal Preference; Children at Higher Risk in Summer, Johns Hopkins University Study
The Dendritic Cells are charged with tumour derived antigens, determinants that distinguish a tumour cell from a normal cell. These antigens are processed by the Dendritic Cell and shuttled to the cell surface in order to present them to T cells. This, however, is not sufficient to prime an immune response against the tumour antigens. The "trick" referred to above is contacting Dendritic Cells with a microbial danger signal. Certain molecules, that are present in microorganisms but not in higher organisms signal the Dendritic Cell the presence of a microorganism in its surroundings and hence danger to the organism.
EMA: First proof of efficacy expected
Activartis is a biotech company based in Vienna. The majority owner is the Austrian pharmaceutical company AOP Orphan Pharmaceuticals AG, which specialises in the development and distribution of pharmaceuticals for Orphan Diseases. Activartis was founded in 2003 as a spin off of the St. Anna Children's Cancer Research Institute, Vienna, Austria. Activartis is currently in phase II of clinical trials for a new kind of Cancer Immune Therapy. The therapeutic technology combines a completely new, patented approach, AV0113, that uses a bacterial danger signal together with the patient's tumour antigens, with the concept of Dendritic Cells already marketed. The aim is to enable the immune system to gain control of the cancer.
participate in a randomised phase II study, GBM Vax, designed to deliver evidence for AV0113's efficacy. GBM Vax has recruited close to 100 Glioblastoma patients. Now we have to wait and see whether patients survive longer when treated with the AV0113 Cancer Immune Therapy.
Dolce Gabbana Belt
Lv White Belt
Louis Vuitton Belt Receipt Template
Gucci Belt Dragon
Brooklyn Dodgers Hats
Diesel Belt For Men
Gucci Belt Pink
Louis Vuitton Mens Belt Buckle
Chicago Bulls Cap 2013
Louis Vuitton Belt Checkered
Hermes Belt Uk
Adidas Cap Star Wars
Michael Kors Belts Women
Chicago Bears Hats
Ferragamo Belt Images
Nike Hat On Women