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AesRx Begins Clinical Trial of AES 103 for Sickle Cell Disease Astex Pharmaceuticals (ASTX) Sees Positive Results From SGI 110 AML Phase 2 Study; Stock Rockets +24.45% at Market Close (August 28, 2013)
NEWTON, MA, September 3, 2013 AesRx, LLC, announced it has received regulatory and ethics committee approval for a Phase 2 clinical trial of its novel Aes 103 anti sickling agent in patients with sickle cell disease (SCD). The Company plans for patient enrollment to start this month.
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Note: References to the National Institutes of Health, its programs or its staff, should not be viewed as an endorsement or implied endorsement of AesRx, its Gucci Belt Drawing
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AesRx Announces Collaboration With National Institutes of Louis Vuitton Mens Belt Blue
This is the first Phase 2 trial of Aes 103 for SCD and as such marks an important milestone in the drug's development. This double blind, placebo controlled study will evaluate the safety and pharmacokinetics of 28 day dosing of Aes 103. In addition, the impact of Aes 103 on several sickle cell clinical endpoints will be evaluated. The trial is part of an ongoing collaboration between AesRx and the National Center for Advancing Translational Sciences (NCATS) through its Therapeutics for Rare and Neglected Diseases (TRND) program. NCATS is one of the National Institutes of Health (NIH).
"Aes 103 is now in Phase 2. This is a major step forward for the program," commented Stephen R. Seiler, AesRx's Chief Executive Officer. "In 2012 we completed a Phase 1 trial in healthy volunteers and recently successfully completed Hermes Belt White And Gold
AesRx Anti Sickling Drug Aes 103 Begins Phase 2 Trial
AesRx's second development program, Aes 210, is targeted to treat certain inflammatory diseases of the lower intestine, including distal ulcerative colitis, pouchitis and radiation induced proctitis. These statements are subject to numerous risks and uncertainties.
Sickle cell disease is a recessive disorder of the hemoglobin which can lead to a wide range of serious, sometimes life threatening, conditions including: chronic hemolytic anemia, chronic pain and acute painful crisis, stroke, acute chest syndrome, and cumulative damage to tissues and organs. More than 100,000 people in the United States are afflicted with sickle cell disease.
a Phase 1/2a trial in patients with stable sickle cell disease. Aes 103 doses from 300mg to 4000mg per day were observed to be safe and well tolerated in both healthy volunteers and sickle cell patients. We have reported the results of the Phase 1 trial (American Society of Hematology, Dec. 2012) and anticipate presenting the results of the Phase 1/2a trial at a major scientific conference later this year. Food and Drug Administration. It is a first in class, orally bioavailable small molecule for the treatment of SCD. AesRx believes it is the only drug currently in human trials that directly blocks cell sickling.
products or services. Additional information about sickle cell disease is available at:
Health (NIH) to Develop Aes 103 for Sickle Cell Disease National Institutes of Health (NIH): Gilead Sciences, Inc. (GILD) Drug Combined With Ribavirin Cures Hard to Treat Hep C Patients
AesRx is a biopharmaceutical company dedicated to the development of treatments for two orphan diseases. The Company's lead program (Aes 103) is targeted to the treatment of sickle cell disease. Sickle cell disease is a recessive disorder of the hemoglobin which can lead to a wide range of serious, sometimes life threatening, conditions including: chronic hemolytic anemia, chronic pain and acute painful crisis, stroke, acute chest syndrome, and cumulative damage to tissues and organs. More than 13 million individuals world wide are afflicted with sickle cell disease. Hugo Boss Belts Uk Aes 103 works by stabilizing sickle hemoglobin in the high oxygen affinity R State. Sickle hemoglobin in the R State cannot polymerize (sickle). In addition, data recently developed at the NIH indicates Aes 103 can stabilize red blood cells against shear stress. Vascular inflammation is a common feature of SCD. It exposes the sickle red blood cells to shear stress which in turn leads to cell death. Aes 103 may help prevent this. AesRx is currently developing Aes 103 in collaboration with the National Institutes of Health.
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